LGA infants display early catch down growth in length and weight without epigenetic changes
نویسندگان
چکیده
Methods Seventy-one singleton infants born at term were classified by birth weight as AGA (10th-90th percentile; n=42) and as LGA (>90th percentile; n=29). Post-natal follow-up until age 1 year was performed with clinical assessments at 3, 6, and 12 months. Assessments included measurement of infants’ weight, length, ponderal index, BMI, as well as head, chest, and abdominal circumference. A subgroup of 38 infants (17 AGA and 21 LGA) was selected for genome-wide DNA methylation analysis. Umbilical cord was collected at birth, and methylation profile on umbilical tissue was analysed using the Illumina Infinium 450K methylation array.
منابع مشابه
Infants born large-for-gestational-age display slower growth in early infancy, but no epigenetic changes at birth
We evaluated the growth patterns of infants born large-for-gestational-age (LGA) from birth to age 1 year compared to those born appropriate-for-gestational-age (AGA). In addition, we investigated possible epigenetic changes associated with being born LGA. Seventy-one newborns were classified by birth weight as AGA (10(th)-90(th) percentile; n = 42) or LGA (>90(th) percentile; n = 29). Post-nat...
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ورودعنوان ژورنال:
دوره 2015 شماره
صفحات -
تاریخ انتشار 2015